Metabolic Syndrome and Viral Pathogenesis: Lessons from Influenza and Coronaviruses.

Metabolic syndrome increases the risk of severe disease due to viral infection. Yet, few6 studies have assessed the pathogenesis of respiratory viruses in high-risk populations. Here, we summarize how metabolic dysregulation impairs immune responses and we define the role of metabolism during influenza and coronavirus infections. We also discuss the use of various in vitro, in vivo, and ex vivo models to elucidate the contribution of host factors to viral susceptibility, immunity, and disease severity.