Prevalence study of the genetic markers associated with slow progression of human immunodeficiency virus type 1 in the Galician population (Northwest of Spain)

Abstract Introduction The deletion in the CCR5 gene (CCR5-Δ32), the HLA-B*27:05, and polymorphisms rs2395029 and rs9264942 have been associated with slower progression of HIV-1. Methods An analysis was performed on 408 patients on follow-up. The analysis of viral load, CD4+ T lymphocytes and other clinical variables since the diagnosis of the infection were collected. Results The prevalence of the genetic markers rs9264942, CCR5wt/Δ32, rs2395029, HLA-B*27:05 was 17.9%, 11.5%, 7.6%, and 6.4%, respectively. Of all the patients, 354 were classified as progressors and 46 as long-term non-progressors (LTNPs). Except for the HLA-B*27:05 allele, other genetic markers were associated with slower progression: CCR5wt/Δ32 ( p  = 0.011) and SNPs rs2395029 and rs9264942 ( p p Conclusion The prevalence of the HLA-B*57:01 allele was higher than described nationally. No association could be found between the HLA-B*27:05 allele and the presence of slower disease progression.