Total Syntheses of (−)‐Huperzine Q and (+)‐Lycopladines B and C

Utilizing a late-stage enamine bromofunctionalization strategy, the twelve-step total synthesis of (−)-huperzine Q was accomplished. Furthermore, the first total syntheses of (+)-lycopladines B and C are described. An unprecedented X-ray crystal structure of an unusual epoxyamine intermediate is also reported, and the synthetic application of this intermediate in natural product synthesis is demonstrated.