DNA methylation and genome imprinting in the zebrafish, Danio rerio: some evolutionary ramifications
1997
Although methylation has been recognized as an important component in a number of developmental processes in mammals, in zebrafish almost nothing is known about this epigenetic modification. This is despite the fact that the zebrafish is becoming increasingly popular as a developmental model system. The little work that has been done on methylation and development in fish concerns genomic imprinting. In mammals, imprinting results in an inability to reproduce parthenogenetically because a genetic contribution from both parents is necessary to successfully complete development. However, this is not true of zebrafish, and a number of the theories that have been presented to explain the evolution of imprinting are not consistent with imprinting in these fish. A new model is presented that discusses some of the potential evolutionary ramifications of methylation and imprinting and that leads to the suggestion that imprinting may actually be a simple genetic mechanism to enhance the efficient evolution of both...
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