A New Set of Amino Acid Descriptors for the Development of Quantitative Sequence-Activity Modelings of HLA-A*0201 Restrictive CTL Epitopes
2008
A new set of amino acid descriptors, SZOTT (Scores of Zero dimension, One dimension, Two dimension, Three dimension) was derived from principal component analysis on a matrix of 1369 descriptors including 0D, 1D, 2D and 3D information of 20 coded amino acids. SZOTT scales were then employed to represent structures of HLA-A*0201 restrictive CTL epitopes, and further, quantitative sequence-activity modelings (QSAMs) were constructed based on partial least squares and back-propagation artificial neural networks. Satisfying results show that structural information related to biological activities of HLA-A*0201 restrictive CTL epitopes can be preferably represented by SZOTT scales, which may be a useful structural representation technique for study of QSAMs of peptides.
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