SAT0649 Correlation between clinical manifestations and 18f-fdg uptake in patients with polymyalgia rheumatica

Background Polymyalgia rheumatica (PMR) is an inflammatory disease characterised by pain and stiffness of the neck, shoulder and pelvic girdles. It can also be accompanied by other non-specific symptoms such as inflammatory low back pain, diffuse lower limb pain and constitutional syndrome. The role of 18F-FDG PET/CT is increasing in the diagnosis of PMR but it remains unknown if there is a correlation between clinical symptoms and 18F-FDG uptake. Objectives Our aim was to asses if the localization of pain of patients with PMR correlates with 18F-FDG uptake in the corresponding region of interest. Methods Retrospective study of 75 patients with PMR and their respective PET/CT scans from a referral centre. PMR diagnosis was based on 2012 EULAR/ACR criteria. Results We evaluated 75 patients (27 men and 48 women) with a mean age ±SD of 68.2±10.7 years. A PET/CT was performed in all of them. Pattern of F-FDG uptake in patients with different clinical manifestations were summarised in the TABLE. Twenty-two out of thirty-three patients (66.7%) with 18F-FDG uptake in sternoclavicular joints had shoulder girdle pain. In all patients with morning stiffness (n=11) an increase of 18F-FDG uptake in shoulders was observed. Twenty-three patients of thirty-two patients (71.8%) with18F-FDG uptake in hips had pelvic girdle pain. The remaining localizations of 18F-FDG uptake in PET/CT scans did not show significant correlations with clinical symptoms. Conclusions In patients with PMR, the presence of shoulder girdle pain seems to correlate with F-18FDG uptake in sternoclavicular joints, morning stiffness with 18F-FDG uptake in shoulders and pelvic girdle pain with 18FDG uptake in hips. No other significant correlations were found between any other symptom and 18F-FDG uptake. Disclosure of Interest None declared