Synthesis and antiproliferative activities of diversely substituted glycosyl-isoindigo derivatives
2006
Abstract In the course of structure–activity relationship studies, diversely substituted 1-(β- d -glucopyranosyl)-isoindigo derivatives were prepared from commercially available indolines. Their antiproliferative activities were evaluated toward a panel of human solid cancer cell lines (PC 3, DLD-1, MCF-7, M4Beu, A549, PA 1), a murine cell line (L929) and a human fibroblast primary culture to get an insight into the substitution pattern required for the best biological potencies.
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