Hearing Status in Adult Individuals with Lifetime, Untreated Isolated Growth Hormone Deficiency

ObjectiveTo evaluate the hearing status of growth hormone (GH)–naive adults with isolated GH deficiency (IGHD) belonging to an extended Brazilian kindred with a homozygous mutation in the GH-releasing hormone receptor gene.Study DesignCross-sectional.SettingDivisions of Endocrinology and Otorhinolaryngology of the Federal University of Sergipe.Subjects and MethodsTwenty-six individuals with IGHD (age, 47.6 ± 15.1 years; 13 women) and 25 controls (age, 46.3 ± 14.3 years; 15 women) were administered a questionnaire on hearing complaints and hearing health history. We performed pure-tone audiometry, logoaudiometry, electroacoustic immittance, and stapedial reflex. To assess outer hair cell function in the cochlea, we completed transient evoked otoacoustic emissions (TEOAEs). To assess the auditory nerve and auditory brainstem, we obtained auditory brainstem responses (ABRs).ResultsMisophonia and dizziness complaints were more frequent in those with IGHD than in controls (P = .011). Patients with IGHD had hig...