Crosslinks in COVID19 as inflammation,thrombosis and dyslipidemia

Background and Aims: Markers of inflamation and thrombosis have been well documented in patients with COVID19 Our aim is to study the muscle markers as Troponin and Creatine Kinase in COVID19 patients and find out the connections among them and possibly with other of their parameters Methods: A total of 345 seriously affected COVID19 patients were admitted to a tertiary hospital from February to July 2020 Their mean age was 63,4years,being 61percent male and on hemodyalisis Their clicnical,anthropometric, laboratory values and therapies were the basis for the construction of a data bank with 16700 informations Statistical analysis was perdormed on the R system,due to the large size of data and for the sake of correlations being done among all the measurements Results: Having CK as reference variable,in descending order,the associations were with CKMB,CRP,Creatinine,D Dimer,LDH,Diabetes,BMI,Fibrinogen and Hypertension When the marked variable was Troponin, associations were CKMB,LDH,DDimer,CK,Diabetes,Fibrinogen,Creatinine,Dyslipidemia,CRP,BMI,Race,Hypertension and Statin use Conclusions: Associations of muscle markers as Troponin and CK were found with all inflammation and thrombosis markers aswell as factors such as Race,Diabetes,Hypertension,Dyslipidemia,BMI and Statins are interrelated in COVID19 infection The large spectrum of concomitant alterations caused by the same disease demonstrates that these factors are not altered independently but by one and the same infectious agent