Modeling the accessibility of the interaction of clonazepan to albumins

This paper shows results obtained from the clonazepam (CNZP) interaction with human and bovine serum albumin study, seeking data on the pharmacokinetics and the binding site for the anxiolytic by comparing the responses of these two proteins to this drug. The quenching response of this experiment show a huge interaction between CNZP and the albumins, that confirm the literature information relative to the high affinity of CNZP with the plasma protein, a long plasma half-life and that the single binding site for this drug can be found in or close to subdomain IB of HSA and BSA.