Selected aspects of immunological disorders in Parkinson disease

: Numerous factors are involved in the pathogenesis of Parkinson's disease, including inflammation in certain regions of the brain. Studies suggest a significant role of microglia in dopaminergic cell injury. Cytokines and apoptosis-related proteins were elevated in the brain and cerebrospinal fluid. The occurrence of autoantibodies against neuronal structures has been found in Parkinson's disease. Disturbed cellular and humoral immune functions in peripheral blood and cerebrospinal fluid of patients have been also reported. An infectious cause of Parkinson's disease has been also discussed for years.