Evaluation of the sensitivity of the novel α4β2* nicotinic acetylcholine receptor PET radioligand 18F-(−)-NCFHEB to increases in synaptic acetylcholine levels in rhesus monkeys

Objective 18F-(−)-NCFHEB (also known as 18F-(−)-Flubatine) is a new radioligand to image α4β2* nicotinic acetylcholine receptors in vivo with positron emission tomography (PET), with faster kinetics than previous radioligands such as 18F-2-F-{"type":"entrez-nucleotide","attrs":{"text":"A85380","term_id":"6733979","term_text":"A85380"}}A85380. The goal of this study was to assess the sensitivity of 18F-(−)-NCFHEB-PET to increases in synaptic acetylcholine concentration induced by acetylcholinesterase inhibitors.