Nitrogen heterocyclic derivatives and Its Application to Pharmaceuticals

The present invention relates to pharmaceutical area, new nitrogen heterocyclic derivatives, their preparation and pharmaceutical, particularly use as a medicament for treating and preventing and treating tissue fibrotic diseases disclosed. The present invention has been disclosed also applications treating tissue fibrotic diseases of the human or animal using the compounds pharmaceutical compositions containing and compositions thereof of the invention that is pharmaceutically acceptable. In particular, renal interstitial fibrosis of the human or animal, glomerulosclerosis, hepatic fibrosis, pulmonary fibrosis, peritoneal fibrosis, myocardial fibrosis, skin fibrosis, post-surgical adhesions, benign prostatic hyperplasia, skeletal muscle fibrosis, scleroderma, multiple sclerosis, pancreatic fibrosis, cirrhosis, muscle, neurofibroma, pulmonary interstitial fibrosis, diabetic nephropathy, find application in the treatment of Alzheimer's disease or vascular fibrotic diseases disclosed. .FIELD 1