Inhibiting pyrimidines of hiv replication.

A compound having the formula # ** (See formula) ** an N-oxide, an addition salt, a quaternary amine or a stereochemically isomeric form thereof, in which # -b1 = b2-C (R2a) = b3-b4 - represents a bivalent radical of formula # -N = CH-C (R2a) = CH-CH = (b-2); # -CH = NC (R2a) = CH-CH = (b-3); # -N = CH-C (R2a) = N-CH = (b-4); # -N = CH-C (R2a) = CH-N = (b-5); # -CH = NC (R2a) = N-CH = (b-6); # -N = NC (R2a) = CH-CH = (b-7); # q is 0, 1, 2; or when possible q is 3 or 4; # R1 is hydrogen; aryl; formyl; C1-6 alkylcarbonyl; C1-6 alkyl; C1-6 alkyloxycarbonyl; C1-6 alkyl substituted with formyl, C1-6 alkylcarbonyl, C1-6 alkyloxycarbonyl, C1-6 alkylcarbonyloxy; (C 1-6) alkyloxyC 1-6 alkylcarbonyl substituted with C 1-6 alkyloxycarbonyl; # R2a is cyano, aminocarbonyl, mono- or di (methyl) aminocarbonyl, C 1-6 alkyl substituted by cyano, aminocarbonyl or mono- or di (methyl) aminocarbonyl, C2-6 alkenyl substituted with cyano, or C2-6 alkynyl substituted with cyano; # each R2 is independently hydroxy, halo, C1-6 alkyl optionally substituted with cyano or -C (= O) R6, C3 cycloalkyl -7, C2-6 alkenyl optionally substituted with one or more halogen or cyano atoms, C2-6 alkynyl optionally substituted with one or more halogen or cyano atoms, C1-6 alkyloxy, C1-6 alkyloxycarbonyl, carboxyl, cyano, nitro , amino, mono- or di (C1-6 alkyl) amino, polyhalomethyl, polyhalomethyloxy, polyhalomethylthio, -S (= O) pR6, -NH-S (= O) pR6, -C (= O) R6, -NHC ( = O) H, -C (= O) NHNH2, -NHC (= O) R6, -C (= NH) R6 or a radical of formula # ** (See formula) ** in which # each A is independently N, CH or CR6; #B is NH, O, S or NR6; # p is 1 or 2; and # R6 is methyl, amino, mono- or dimethylamino or polyhalomethyl; # L is C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, C3-7 cycloalkyl, in which each of said aliphatic groups may be substituted with one or two substituents independently selected from # * C3-7 cycloalkyl, # * indolyl or isoindolyl, each optionally substituted with one, two, three or four substituents each independently selected from halo, C1-6 alkyl, hydroxy, C1 alkyloxy -6, cyano, aminocarbonyl, nitro, amino, polyhalomethyl, polyhalomethyloxy and C1-6 alkylcarbonyl, # * phenyl, pyridinyl, pyrimidinyl, pyrazinyl or pyridazinyl, in which each of said aromatic rings may be optionally substituted with one, two, three, four or five substituents each independently selected from the substituents defined for R2; or # L is -X-R3 in which # R3 is phenyl, pyridinyl, pyrimidinyl, pyrazinyl or pyridazinyl, in which each of said aromatic rings may be optionally substituted with one, two, three, four or five substituents selected each one independently among the substituents defined for R2; and # X is -NR1-, -NH-NH-, -N = N-, -O-, -C (= O) -, -CHOH-, -S-, -S (= O) - or -S (= O) 2 -; # Q represents hydrogen, C1-6 alkyl, halo, polyhalo-C1-6 alkyl or -NR4R5; and # R4 and R5 are each independently selected from hydrogen, hydroxy, C1-12 alkyl, C1-12 alkyloxy, C1-12 alkylcarbonyl, C1-12 alkyloxycarbonyl, aryl, amino, mono- or di (C1-12 alkyl) amino , mono- or di (C1-12 alkyl) aminocarbonyl in which each of the above-mentioned C1-12 alkyl groups may be optionally and each individually substituted with one or two substituents each independently selected from hydroxy, C1-6 alkyloxy , C1-6 hydroxy-alkyloxy, carboxyl, C1-6 alkyloxycarbonyl, cyano, amino, imino, mono- or di (C1-6 alkyl) amino, polyhalomethyl, polyhalomethyloxy, polyhalomethylthio, -S (= O) pR6, -NH- S (= O) pR6, -C (= O) R6, -NHC (= O) H, -C (= O) NHNH2, -NHC (= O) R6, -C (= NH) R6, aryl and Het ; or # R4 and R5 taken together may form pyrrolidinyl, piperidinyl, morpholinyl, azido or mono- or di (C 1-12 alkyl) aminoC 1-4 alkylidene; #Y represents hydroxy, halo, C 3-7 cycloalkyl, C 2-6 alkenyl optionally substituted with one or more halogen atoms, C2-6 alkynyl optionally substituted with one or more halogen atoms, C1-6 alkyl substituted with cyano or -C (= O) R6, C1-6 alkyloxy, C1-6 alkyloxycarbonyl, carboxyl, cyano, nitro, amino, mono- or di (C1-6 alkyl) amino, polyhalomethyl, polyhalomethyloxy, polyhalomethylthio, -S (= O) pR6, -NH-S (= O) pR6, -C (= O) R6, -NHC (= O) H, -C (= O) NHNH2, -NHC (= O) R6, -C (= NH) R6 or aryl; # aryl is phenyl or phenyl substituted with one, two, three, four or five substituents each independently selected from halo, C 1-6 alkyl, C 3-7 cycloalkyl, C 1-6 alkyloxy, cyano, nitro, polyhalo-C 1-6 alkyl and polyhalo-C 1-6 alkyloxy; #Hetes an aliphatic heterocyclic radical or aromatic; said aliphatic heterocyclic radical is selected from pyrrolidinyl, piperidinyl, homopiperidinyl, piperazinyl, morpholinyl, tetrahydrofuranyl and tetrahydrothienyl wherein each of said aliphatic heterocyclic radicals may be optionally substituted with an oxo group; and said aromatic heterocyclic radical is selected from pyrrolyl, furanyl, thienyl, pyridinyl, pyrimidinyl, pyrazinyl and pyridazinyl in which each of said aromatic heterocyclic radicals may be optionally substituted with hydroxy.