Histological Characterization of Age-Related Skin Changes Following The Use Of Picosecond Laser: Low Versus High Energy.

BACKGROUND: Fractional lasers have become widespread in dermatology owing to their efficacy and safety. OBJECTIVE: Comparative analysis of histological features after laser rejuvenation using a 1064-nm fractionated handpiece picosecond laser with different energy fluence levels (1.1 J/cm2 or 2.1 J/cm2 ). PATIENTS AND METHODS: An open-label, study of 28 women aged 36-60 years with signs of age-related photodamage and skin changes of the face and neck was conducted using a fractional picosecond 1064 nm laser in low versus high fluence. RESULTS: The clinical assessment at three weeks showed more pronounced effect on facial skin rejuvenation with the higher fluence of 2.1 J/ cm2 compared to 1.1 J/cm2 . CONCLUSION: The effect and safety of laser rejuvenation using a picosecond laser has been shown with more pronounced histological effects at higher fluences. This article is protected by copyright. All rights reserved.