Effect of Pentoxifylline against Doxorubicin-Induced Nephrotoxicity in Rabbits

This study was designed to evaluate the possible protective effect of pentoxifylline against doxorubicin-induced nephrotoxicity in rabbits. The animals groups were divided into a control group received 5 ml of normal saline intraperitoneally for 5 days, doxorubicin group that received (25mg/kg) intraperitoneally at day 3 and then the animals were sacrificed at day 5 and pentoxifylline + doxorubicin group (80mg/kg/day) intraperitoneally administered for 3 days before and two days after doxorubicin (25mg/kg) intraperitoneally administered at day 3 and then the animals were sacrificed at day 5. All animal were anasthesized by ether and sacrificed, after 48 hour after doxorubicin administered, at day 5. The spectrophotometry measuring of kidney function parameters such as serum urea and creatinine level. In addition, the oxidative stress parameters that included malondialdehyde and reduced glutathione in the renal tissue homogenate. The results obtained by analysis of data, by using independent t-test, showed a significant improvement of urea and creatinine levels in pentoxifylline + doxorubicin group as compared to doxorubicin group at p ≤ 0.05. Also, reduction effect of pentoxifylline on malondialdehyde and a significant elevation of GSH. The results of this study led to conclude the beneficial effect pentoxifylline against doxorubicin-induced kidney toxicity in rabbit's models.