Atmospheric pressure ion-sampling system for liquid chromatography/mass spectrometry analyses on a benchtop mass spectrometer

A commercial benchtop GC/MS mass spectrometer has been modified for liquid chromatography/mass spectrometry (LC/MS) applications. The modifications and concepts are straightforward, and the cost of the modification is minimal provided appropriate pumping is available. The system can sample gas-phase ions formed at atmospheric pressure either by pneumatically assisted electrospray (ion spray) or by atmospheric pressure chemical ionization (APCI).