The effects of dietary Immunogen on innate immune response, immune related genes expression and disease resistance of rainbow trout (Oncorhynchus mykiss).

Abstract This study investigates the effects of prebiotic Immunogen ® on lysozyme, TNFα and HSP70 gene expression in head kidney, humoral innate immune parameters and resistant to Aeromonas hydrophila of rainbow trout. 120 healthy rainbow trout (81.65 ± 1.49 g) were distributed in six fiberglass tanks assigned to two groups fed control or diet supplemented with 2 g kg −1 Immunogen ® for 45 days. The results revealed that administration of Immunogen ® significantly ( P P ® fed fish at the end of trial. Humoral innate immune parameters (lysozyme activity, ACH50 and bactericidal activity) were significantly ( P ® supplemented diet. However, significant ( P ® . Rainbow trout fed with 2 g kg −1 Immunogen ® showed remarkably higher resistance against A. hydrophila (64.44% survival) compared to the control group (24.44% survival). These results confirm that Immunogen ® can up regulates immune related genes expression, stimulates immune response that per se enhances disease resistance in rainbow trout.