Preparation Technique of Technetium-99m-Labeled Nanoparticles of Fe@C with Modified Surface

The authors have researched the possibility of radioactive 99mTc labeling of the surface of carbon-coated nano-sized ferrum Fe@C particles as well as Fe@C (IDA) particles modified by aryldiazonium tosilates. Non-modified particles proved to absorb up to 11.2 % of 99mТс injected amount. The value of atomic absorption does not exceed 0.736∙10-9 g-at 99mТс per 1 g of Fe@C. No physical absorption is observed on modified particles of Fe@C (IDA). In chemical interaction of the particles with 99mTc in the presence of a reducing agent, Sn (II), the yield of the labeled product increases 1.5 times and reaches 21.3% of the total induced radioactivity of the radionuclide.