Role of ATP sensitive potassium channel on 7 -hydroxy flavone induced antinociception and possible association with changes in glycaemic status

Opioid type of analgesics open A TP sensitive potassium channel at th e cellular level to produce antinocicepti ve re sponse. These channels have also been shown to modulate insulin secretion by the pancreas. 7-hydroxy flavone, an anti nociceptive agent shown to act through opioid pathways was investigated for its effect on glycaemic state and associated algesic state. The involvement of ATP sensitive potassium channel in the action was examined by using glybenclamide. The result reveal that 7-HF per se did not eli cit any sign ificant change in the glycaemic state simultaneously eliciting antinociceptive response as tested by aceti c acid induced abdominal constriction assay procedure. G!ibenclamide treatment attenuated the ant in ociceptive effect of 7-HF and while maintained it s hypoglycaemic response. The present finding suggest that 7-HF induces antinociception like morphine, utili se A TP sensitive potassium channel at the cellular level and do not suggest a cause-effect relationship between the changes in th e glycaemic and algesic state. Possibly, in sulin which is controlled by A TP sensitive potassium channel at the cellular level might also modulate antinociccption exhibiting a cause­ effect relationship between them.