NGAL -ранний биомаркер острого повреждения почек после резекции почки и нефрэктомии

THE AIM OF STUDY was to find out the beginning of the acute kidney injury (AKI) after partial or radical nephrectomy. PATIENTS AND METHODS. 17 patients with renal cell carcinoma were treated either via radical (5 cases) or partial (12 cases) nephrectomy. The procedures were performed through open, laparoscopic or robotic approaches. Partial nephrectomies were made under regional (local) ischemia by putting special clamps on renal parenchyma. The serum creatinine was measured before procedure and 24 h later. Plasma NGAL levels was measured before surgery and 2 hours later. Urine NGAL was measured before surgery after 2, 4 and 8 hours. RESULTS. The histological diagnosis was RCC in all cases. In groups of radical and partial nephrectomy initial level of blood serum creatinine, blood serum NGAL and urine level didn’t exceed normal values. In radical nephrectomy group urine NGAL level increased 2 hours after surgery. Maximal values were detected at 8 hours after surgery (increase of factor to 123,4±29,1 ng/ml). In group of partial nephrectomy urine NGAL begin to increase at 2 hours after surgery too. Maximal values were detected after 8 hours after surgery 25,4±14,6 ng/ml. CONCLUSIONS. Concentration of urine NGAL over time provide to reveal acute kidney injury 2 hours after surgery.