Adoptive transfer of the entire gld (generalized lymphoproliferative disease) syndrome in nude beige mice by a single gld thymocyte graft.

Abstract C57BL/6 nude beige mice (B6 nubq ; no T cell, no NK activity) were used as recipients for the adoptive transfer of thymocytes from B6 gld mice ( generalized lymphoproliferative disease ) which are a model of systemic lupus erythematous. The [ gld → nubg ] chimeras showed several similarities with gld control mice including the T cell disorders (lymphoproliferation and Con A-response deficiency of splenocytes) and B cell disorders (hyperglobulinemia and elevated anti-single-stranded DNA antibody titers). This suggests that the gld lymphoproliferative disorder has a thymic origin (and does not result from an abnormally extrathymic T cell development) and that the gld T cells have an essential role for the emergence of the disorders of both the T and B cells.