Bench-to-bedside translation of Interleukin-15 for immunotherapy: principles and challenges.
2020
Since its discovery 25 years ago by our group and Grabstein et al. [1–3], interleukin-15 (IL-15) has attracted much attention in terms of its biological activities, mechanism of action and therapeutic modulations under various physiological and pathological conditions. In particular, the stimulatory effects of IL-15 on the proliferation and effector functions of natural killer (NK) cells and CD8+ T cells make it a promising component for immunotherapy in the treatment of malignancies and infectious diseases [4,5]. Here, we present a brief summary on the biological principles of how IL-15 exerts immunostimulatory effects on cells, the clinical investigations on IL-15-based therapeutic agents, and the challenges for safe and efficacious delivery of IL-15 in patients.
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