Cerebrospinal fluid and multiple sclerosis

: A survey of the relevant diagnostic methods in the cerebrospinal fluid in multiple sclerosis is given. In over 90% positive results are obtained, showing the inflammatory CNS-process or myelin break down. Personal findings demonstrate the relevance of lymphocytic transformation in CNS inflammatory diseases. In 73% of definitive MS cases transformed lymphocytes occurred, commonly associated with a pathological IgG/Albumin ratio, but in 23% of chronic progressive cases in isolation. Under unselected cerebrospinal fluids with transformed lymphocytes and a cell count under 16 per micro 1 multiple sclerosis was suspected clinically in 70%, in further 20% other inflammatory diseases were present while only 10% unspecific cases occurred.