SOLID-PHASE SYNTHESIS OF TRISUBSTITUTED GUANIDINES
1997
Abstract The solid-phase synthesis of trisubsituted guanidines is reported via aza-Wittig coupling of a solid-supported alkyl iminophosphorane with an aryl or alkyl isothiocyanate to generate the corresponding solid-supported carbodiimide which is then reacted with a primary or secondary amine to afford the desired trisubstituted guanidines.
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