Effects of pyrroloquinoline quinone on proliferation and expression of NF-κB in cultured Schwann cells

[Objective] To investigate the effects of pyrroloquinoline quinine(PQQ)on proliferation and expression of NF-κB of Schwann cells.[Methods]Schwann cells were cultured from sciatic nerves of SD rats in vitro.The Schwann cells were identified and purified by immunofluorescence of S-100 and Ara-C.Experimental group with was 100 nmol/L of PQQ and control group were set up.The expression of NF-κB in Schwann cells was determined by RT-PCR and Western blotting.[Results]The expression of NF-κB were up-ragulated by PQQ in cultured Schwann cells(P0.05).[Conclusion]PQQ could promote the proliferation of Schwann cells and up-regulation of NF-rd3 play an important role in this process.