Clinical features and prognosis of renal cell carcinoma patients with peritoneal invasion only

Objective To study the clinical features and prognosis of renal cell carcinoma patients with peritoneal invasion but without lymphatic or systemic metastasis (T4N0M0).Methods We reviewed patients with pathological stage of T4N0M0 from Jan.1999 to Feb.2012.There were 16 patients (9 males,7 females) met the inclusion criteria.There were 6 tumors on the left while other l0 on right.The median patient age was 65 (ranged from 33-78) years,the medium size of the mass was 8.5 (ranged from 5.5-17.0)cm.Peritoneum was invaded in all these patients and all of them had radical nephrectomy and resection of a contiguous peritoneum successfully.Results These patients accounted for 0.21％ (16/2889) of all renal cell carcinoma cases or 21.62％ (16/74) of all T4NxMx cases during this period.All patients were followedup for 18-134 month.Metastases were found in 8 patients at a median 6.5 (ranged from 1-41) month after surgery.9 patients were survival with disease-free,1 patient were survival with disease progression,6 patients died after surgery.The 3 years and 5 years of cumulative survival rate were 79.32％ and 64.90％,respectively.Conclusions The incidence of renal cell carcinomas with peritoneal invaded only is rare.Patients accept a successfully radical nephrectomy and resection of a contiguous peritoneum will have a good prognosis. Key words: Renal cell carcinoma;  Surgery;  Prognosis