Alternative mechanism of action of DNP PtIV prodrug: intracellular cisplatin release and mitochondria-mediated apoptotic pathway
2021
In a recent research paper Dr. Suxing Jin et al. reported two multispecific PtIV complexes DNP and NP with non-steroidal anti-inflammatory drug naproxen (NPX) as the axial ligand(s). Herein, we clarify the mechanism of action of DNP, its therapeutic target and intracellular redox-status.
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