Clinical Significance of Serum miR-128 and miR-720 Relative Expressionsin Patients with Glioma

Objective To explore the diagnostic values of serum miR-128 and miR-720 relative expressions in patients with glioma.Methods The serum miR-128 and miR-720 relative expressions were detected by TaqMan MicroRNA Assays Real-time PCR in 54 low-grade glioma patients group,57 high grade glioma patients group and 62 healthy controls group.Results Compared to the healthy control group,miR-720 relative expression in patients with low-grade glioma were showed significant difference,miR-128 and miR-720 relative expressions in the high-grade glioma group showed significant difference.Compared to the low-grade glioma group,miR-128 and miR-720 relative expressions in the high-grade glioma were showed significant difference.The diagnostic sensitivity and specificity of miR-128 and miR-720 relative expressions for discriminating the healthy control group and the glioma group were 92.3% and 87.2%,respectively.The diagnostic sensitivity and specificity for discriminating the low-grade glioma group and the high-grade glioma group were 84.3% and 88.9%,respectively.Conclusion The combined detection of miR-128 and miR-720 relative expressions may provide an auxiliary method for the clinical diagnosis and classification of glioma.