Acute health effects of short-term use of e-cigarette on respiratory and cardiovascular system

The health effects of using e-cigarette has not been fully understood. The aim of the study was to assess the impact of 5 min e-cigarette usage on respiratory and cardiovascular system, compared to cigarette smoking. 120 healthy adults (aged 21.7±2.1yo) were divided into 4 groups (n=30 each): control (C), smokers (S), e-smokers (E) and dual users (D). Heart rate, blood pressure, saturation, exhaled CO, exhaled NO, airway temperature, spirometry were assessed before and after (in 1 min and 30 min) 5 min of use of an e-cigarette (12mg/ml of nicotine) or cigarette. In C group measures was performed twice, before and after 5 min of simulation of e-cigarette usage (without e-liquid). E-cigarette and cigarette smoking causes decrease in exhaled NO (p=0.0001) after 1 min by 2.1ppb; 1.47ppb and 2.2ppb in S, E, and D groups respectively. After 30 minutes the concentration of NO increased, reaching a level comparable to the initial values. The use of e-cigarette did not affect the values of saturation and exhaled CO. Cigarette smoking increases (p=0.0001) exhaled CO (from 4.1 to 7.77 mean by 3.7ppm). Increase in airway temperature were observed in 1 (E: by 0.15°C, p=0.03; D: by 0.17°C, p=0.02) and 30 min (E: by 0.22°C, p=0.03; D: by 0.21°C, p=0.003) after e-cigarette use, and in 30 min (S: by 0.3°C, p=0.0001) after cigarette smoking. Among S and D, PEF and MEF75 decreased in 1 min after smoking. E-cigarette and cigarette smoking causes increase (p 0.05). E-cigarette and cigarette using cause acute effects of the respiratory and circulatory system