Formulation and development of Oral Fast Dissolving Tablet Using etoricoxib

The basic objective of this study was to prepare oral fast dissolving tablet to achieve better patient compliance. Often times people experience inconvenience in swallowing conventional dosage forms such as tablet when water is not available, in such cases tablets that can rapidly dissolve or disintegrate in the oral cavity have attracted a great deal of attention. Fast dissolving tablets are those when put on tongue disintegrate instantaneously releasing the drug which dissolve or disperses in the saliva. The faster the drug into solution, quicker the absorption and onset of action. Absorption of the drug is increased and first pass metabolism is reduced. The lowest disintegration time and high drug release was shown by KM3 formulation and selected as optimized formulation. From present study it can be concluded that bitter taste of Etoricoxib can be successfully masked with aspartame and solubility of Etoricoxib is increased using urea as hydrophilic carrier by kneading method. Well palatable and patient compliant Fast Dissolving Tablet can successfully prepared using Kneading method. The prepared optimized tablet showed quick disintegration as well as rapid dissolution as compared to marketed tablet. Thus, the Rapid Disintegrating Tablet of bitter drug having bitter taste and pleasant mouth feel can be successfully formulated.