Nepafenac vs bromfenac: A comparative study to determine their role in maintaining mydriasis during cataract surgery

Aim: To assess and compare the role of topical nepafenac (0.1%) v/s bromfenac (0.09%) in sustaining intra-operative mydriasis while doing cataract extraction. Study Design: Prospective, randomized study. Place and Duration of Study: Regional Institute of Ophthalmology, Rajendra Institute of Medical Sciences (RIMS), Ranchi (Jharkhand). The duration of study was from June 2019 to February 2020. Materials and Methods: Topical NSAIDs (nepafenac and bromfenac) and carboxymethylcellulose (control) were administered to the cataract patients before Phaco surgery. Pupillary diameters were assessed first at starting of surgery and then after completing the surgery; average values were calculated for the three groups. Study was done on 90 patients having age 40-80 years, planned for cataract surgery with PCIOL implantation. Results: in group A (i.e. control) reduction in pupillary diameter came out to be more statistically significant unlike in group B (nepafenac) and in group C (bromfenac) (p Conclusion: Both nepafenac (0.1%) and bromfenac (0.09%) administered a day before operation are helpful in sustaining pupil size intra-operatively but bromfenac comparatively seemed to be better than nepafenac in sustaining mydriasis during SICS/Phaco. Keywords: Bromfenac, Cataract, Mydriasis, Nepafenac.