Eszopiclone: a nonbenzodiazepine that effectively improves sleep maintenance and initiation in patients with insomnia

Eszopiclone is a nonbenzodiazepine hypnotic that modulates the γ-amino butyric acid A-receptor complex. It has been shown to be effective at improving sleep initiation and maintenance in trials lasting up to 12 months and has been associated with improvement in medical disorders with high rates of comorbid insomnia including depression, anxiety, pain disorders and menopause. Eszopiclone treatment has generally been well tolerated and produced significant improvements in next-day functional parameters across multiple studies.