A Simple, General and Efficient Method for O and N-Retinoylation. Application to the Synthesis of 2-Retinoyl-Lecithin.

Abstract The synthesis of the new l-stearoyl-2-retinoyl-glycero-3-phosphorylcholine by coupling of retinoic acid and lysolecithin with DCC-DMAP (1.2 eq.) is reported. This method is applied to O and N-retinoylation of uncharged organic substrates such as aliphatic alcohols, free hydroxyl anomeric sugars, aromatic amines and C-protected α-aminoacids.