Evaluation of clinical outcome of cancer related thrombophilia: A Review

Acquired thrombophilic state associated with a significant risk of thrombosis is frequently encountered in malignancy. Venous and arterial thromboembolism is a common complica-tion and patients with cancer, also present with a hypercoagulable state, even in the absence of thrombosis. Furthermore, clotting activation may play a role in tumor progression. The pathogenesis of thrombosis in cancer is multifactorial; however, a relevant role is attributed to the tumor cell capacity to interact with and activate the host haemostatic system. Among other factors, the prothrombotic action of antitumor therapies is also important. New ap-proaches of the prevention and cure of thrombosis in cancer and the hypothesis that the strategies to inhibit clotting mechanism may favorably affect malignant disease are gaining increasing interest.