운동 빈도가 노화된 흰쥐 골격근 내 미토콘드리아 생합성 및 동화작용 신호경로 인자의 발현에 미치는 영향

The purpose of this study was to investigate the effects of exercise frequency different on expression of mitochondrial biogenesis and anabolic signaling pathway factors in aged rats skeletal muscle. The aged rats in four groups exercises: young control (YC group, n=5), old control (OC group, n=5), old exercise 3days/week (0E3 group, n=7), old exercise 5days/week (OE5 group, n=6) on a treadmill run with an intensity of 21m/min, 10° intensity inclination five times for a week during 6 weeks. After exercise training, expression of the p-AMPK, PGC-1α, SIRT-1, HSP78 and IRS-1, GLUT-4, p-mTOR levels were increased significantly in OE5 groups. The major finding of this study was that OE5 groups contribute to enhance mitochondrial biogenesis and anabolic signaling pathway in aged skeletal muscle than in OE3 groups.