A DNA–linker–DNA bifunctional probe for simultaneous SERS detection of miRNAs via symmetric signal amplification

In this work, using a dual functional DNA–linker–DNA (DLD) probe, a new concept of a symmetric signal amplification (SSA) reaction is introduced to simultaneously analyze miRNAs. By coupling the surface-enhanced Raman scattering (SERS) technology with symmetric amplification modes, this flexible biosensing system exhibits high sensitivity and specificity.