Study of free radical oxidation of lipids in cerebrospinal fluid of hydrocephalic children

: The levels of free radical production, malondialdehyde concentration and antioxidant activity were estimated in ventricular liquor of the infants with primary hydrocephalus. It was shown that even in the case of uncomplicated hydrocephalus significant disorders in brain metabolism took place. In the patients with inflammatory or hemorrhagic complications the levels of malondialdehyde and free radicals were markedly increased as compared to the infants with "pure" hydrocephalus. The most significant disorders were revealed in the case of hemorrhagic complications. These data indicate the necessity of lipid peroxidation evaluation in liquor of the patients with hydrocephalus and help to workout indications for antioxidants including into the common therapy of this decrease.