Adenylate cyclase activity of human nasal polyps during stimulation of serotonin biosynthesis in vitro

The tissue of human nasal polyps possesses adenylate cyclase activity. After injection of reserpine (1 mg) into the tissue of nasal polyps, to activate serotonin biosynthesis in the tissue, a significant increase in adenylate cyclase activity was observed; during the first minutes of incubation of the polyp with reserpine, activity increased tenfold. The role of the adenylate cyclase system was confirmed in the initial stages of morphological and biochemical differentiation accompanying serotonin biosynthesis in human nasal polyps.