FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS CISAPRIDE CITRATE
2021
The objective of the Present study is to develop a pharmaceutically stable sustained release matrix tablets of Cisapride citrate and perform the pre-compression, post compression and in-vitro evaluation studies of developed formulation. In this study sustained release matrix tablets of Cisapride citrate were prepared by wet granulation method using Magnesium stearate, Talc, Lactose, Colloid silicon dioxide HPMC in various concentrations. All the formulations have showed acceptable Pharmacopeial standards. Formulation F9 have extended the release of Cisapride citrate upto 12 h. Model fitting analysis for formulation F9 fitted in the zero order model and korsemeyer- peppas model. The “n” values obtained from the peppas-korsemeyer equation suggested that, drug release was non-fickian diffusion mechanism. Successful formulation was found stable after evaluation for physicochemical parameters when kept for 30 days at room temperature, 40 oC and 2-8 oC
Keywords: HPMC.
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