Comparative Risks of Nonsteroidal Anti-Inflammatory Drugs on CKD.

Background and objectives There have been doubts about the association between nonsteroidal anti-inflammatory drug use and worsening kidney function, and whether there is a difference between risks of individual nonsteroidal anti-inflammatory drugs is presently unclear. Therefore, this study aimed to evaluate the association between nonsteroidal anti-inflammatory drug exposure and the risk of incident eGFR Design, setting, participants, & measurements From 2008 to 2017, a total of 1,982,488 subjects aged 18 years or older with baseline eGFR ≥60 ml/min per 1.73 m2 were enrolled in this retrospective cohort study. Multivariable Cox proportional hazards regression adjusted for each patient’s baseline characteristics was adopted to examine the association between nonsteroidal anti-inflammatory drug and incident eGFR Results After a median follow-up duration of 6.3 (interquartile range, 3.3–9.4) years, 271,848 cases (14%) of incident eGFR Conclusions Nonsteroidal anti-inflammatory drug exposure was associated with higher risks of incident eGFR Podcast This article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2021_04_28_CJN18501120.mp3