Cyclin D1 and p57 expression in advanced ovarian epithelial carcinoma: A GOG study.

5086 Background:The aim of this study was to investigate expression of cyclin D1 and p57 in advanced epithelial ovarian cancer and their association with progression free survival (PFS), overall survival (OS), clinical response and evidence of disease at second look laparotomy (SLL). Methods:Of 410 women in GOG-0111(a randomized study of cyclophosphamide/cisplatin vs. paclitaxel/cisplatin in stage III and IV ovarian cancer) 139 had available formalin-fixed and paraffin-embedded tumor blocks. Ninety-eight underwent immunocytochemical staining for cyclin D1 and 121 for p57. Cyclin D1 and p57 expression were dichotomized at their medians by percent of positive tumor cells. Fisher’s exact tests were used to compare patient characteristics. PFS and OS for each were compared using Cox proportional hazards models (unadjusted and adjusted for age and stratified by stage, grade, treatment, measurable disease, and histologic cell-type). Response to therapy and proportion with positive SLL were also compared. Result...