Is it all MIS-C? - Unusual findings in a series of nine German patients with multi-system inflammatory syndrome in children (MIS-C) after SARS-CoV2 infection.

Abstract Objectives Multi-system inflammatory syndrome in children (MIS-C) is a post-viral inflammatory vasculopathy of children and adolescents following Covid-19 infection. Since the incidence of SARS-CoV-infections has been increasing in Germany since October 2020, we observe an increasing number of children presenting with MIS-C. Design We present detailed clinical charactersitics of a cohort of nine children with MIS-C admitted to a tertiary PICU at the University Hospital of Cologne between March 2020 and February 2021. Results The clinical sings and sypmtoms are largerly in line with recent reports. All but one patient had positive SARS-CoV-2 antibodies. Latency form infection to MIS-C was 4-6 weeks. Two children presented with unuauals fundings: A girl had encephalomyelitis and an boy developeed MIS-C side to side with acute leukemia. Conclusion MIS-C has been increasing in Germany paralell to SARS-CoV-2 infections. Rarely, unuasual findings may be associated with MIS-C.