Correlation of methylthioadenosine phosphorylase (MTAP) loss with response to anti-folate therapy in urothelial bladder carcinoma (UBC).

Omar Alhalabi,Jianfeng Chen,Matthew T. Campbell,Rebecca Slack-Tidwell,Guangchun Han,Wei Lien Wang,Jian H. Song,Sumankalai Ramachandran,Lidia López,Anh Hoang,Arlene O. Siefker-Radtke,Mark Titus,Charles C. Guo,Gary E. Gallick,Pavlos Msaouel,Eleni Efstathiou,Christopher J. Logothetis,Thai H. Ho,Linghua Wang,Jianjun Gao

Correlation of methylthioadenosine phosphorylase (MTAP) loss with response to anti-folate therapy in urothelial bladder carcinoma (UBC).

2019

4521Background: The MTAP gene encodes an essential enzyme for the salvage pathway of nucleotide synthesis and is frequently deleted in UBC. Anti-folate agents such as pemetrexed can effectively inh...

Keywords:

Cancer research
Carcinoma
Pathology
Methylthioadenosine phosphorylase
Medicine
Gene
Nucleotide synthesis
Nucleotide salvage
Enzyme
Pemetrexed

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