EFIKASI SUPLEMEN BESI-MULTIVITAMIN UNTUK PERBAIKAN STATUS BESI REMAJA WANITA

EFFICACY OF IRON-MULTIVITAMIN SUPPLEMENT FOR IMPROVING THE IRON STATUS OF ADOLESCENT FEMALES The study was aimed to analyze the efficacy of supplementation iron-multivitamin for improving the iron status of adolescent females through the double-blind trial. Subjects were 224 of the first grade university students (IPB) who were randomly allocated to three study groups through a double blind trial. The first group received only placebo (control group); the second group received 60 mg iron, 250 ug folate (B-F group); the third group received 60 mg iron,800 ug folate, 4200 ug retinyl acetate, 500 mg vitamin C, and 16.8 ug vitamin B12 (B-MV group). All supplements were distributed and consumed weekly during 25 weeks. The mean changes in Hb, STfR and SF among the groups were tested with Ancova and adjusted with BMI; capsule compliance; food/snack compliance; adequacy of energy, protein, vitamin A, vitamin C, iron; and baseline value of Hb, STfR, SF. The results showed the demographics and nutritional characteristics of samples were not significantly different. At the baseline, the mean of haemoglobin (Hb=126.2±13.1 g/l) and serum ferritin (SF=18.3±15.9 ug/l) were not significantly different among the three groups (p 0.05). The B-MV group significantly lower decreased in STfR (-4.2 mg/l) and higher increased in SF (+13.4 ug/l) compared to B-F and control group (p<0.05). Meanwhile, only the STfR in B-F group (-1.3 ug/l) was significantly lower than control group (p<0.05). This implied the important of the multi-vitamin to complement the iron supplementation. Keywords : haemoglobin (Hb), serum transferrin receptor (STfR), serum ferritin (SF), iron status, iron-multivitamin, iron-folate, adolescent female