Platelet Extracellular Vesicles Drive Inflammasome-IL1β-dependent Lung Injury in Sickle Cell Disease

Ravi Vats,Tomasz Brzóska,Margaret F. Bennewitz,Maritza A. Jimenez,Tirthadipa Pradhan-Sundd,Egemen Tutuncuoglu,Jude Jonassaint,Edgar Gutierrez,Simon C. Watkins,Sruti Shiva,Melanie J. Scott,Adrian E. Morelli,Matthew D. Neal,Gregory J. Kato,Mark T. Gladwin,Prithu Sundd

Platelet Extracellular Vesicles Drive Inflammasome-IL1β-dependent Lung Injury in Sickle Cell Disease

2019

Ravi Vats
Tomasz Brzóska
Margaret F. Bennewitz
Maritza A. Jimenez
Tirthadipa Pradhan-Sundd
Egemen Tutuncuoglu
Jude Jonassaint
Edgar Gutierrez
Simon C. Watkins
Sruti Shiva
Melanie J. Scott
Adrian E. Morelli
Matthew D. Neal
Gregory J. Kato
Mark T. Gladwin
Prithu Sundd

Rationale: Intra-erythrocytic polymerization of hemoglobin S promotes hemolysis and vaso-occlusive events in the microvasculature of sickle cell disease (SCD) patients. Although platelet-neutrophil...

Keywords:

Hemoglobin
Diabetes mellitus
Inflammasome
Anesthesia
Acute chest syndrome
Platelet
Pathology
Lung
Extracellular
Hemolysis
Medicine
Cell
Disease
dependent lung
Immunology

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