Evaluation of a new composite score combining SPICE and Protrusion Angle scores to distinguish submucosal lesions from innocent bulges.

Introduction/Aims In capsule endoscopy (CE), small bowel subepithelial lesions (SBSL) are difficult to distinguishing from innocent mucosal protrusions. The SPICE score (smooth, protruding lesions index on CE) and a score that assesses the SBSL protrusion angle were developed. We intend to determine if a composite score is superior to the proposed models. Methods All CE between 01/2010 and 12/2020 were included if a smooth, round protruding lesion was identified. Both scores and a composite score (SPICE>2 and Angle 2 points, the SPICE score has a sensitivity of 64.7% and specificity of 94.2%. The composite score had a sensitivity, specificity, positive and negative predictive value of 47.0%, 100%, 100% and 65.4%. Conclusion We propose that in cases where both a SPICE>2 and angle of <90o are obtained, additional follow-up investigation should always be undertaken, as the likelihood of SBSL is high.