Cardioprotective effect of Tridax procumbens Linn in Isoproterenol Induced Myocardial Infarction in rats

The study was designed to evaluate the hydro-alcoholic extract of Tridax Procumbens Linn (THAE) on lipids, lipoproteins and antioxidants activity in isoproterenol (ISO) induced myocardial infarcted rats. Myocardial infarction was induced by ISO (85mg/kg, s.c.) for two consecutive days at an interval of 24 hours. Rats were pretreated with THAE (100 and 200mg/kg, oral) for a period of 20 days and (ISO) was injected on 21 and 22 days at 24 hr intervals and after 24hr blood was collected through retro-orbital plexus for the estimation biochemical and antioxidant parameters. ISO caused a significant increase in the concentration of total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C) and lipid peroxidation (LPO) whereas a significant decrease in high-density lipoprotein cholesterol (HDL-C). ISO administration also significantly decreased paraoxonase (PON) enzyme. Oral pretreatment of THAE at doses 100 and 200mg/kg for 20 days challenged with a concurrent injection of ISO (85mg/kg bw) on 21 and 22 days significantly attenuated these alterations and restored the levels of lipids, lipoproteins. In addition, THAE significantly alleviated the serum antioxidants enzymes PON, LPO and Catalase (CAT). The present findings shows that pretreatment of THAE in ISO injected rats significantly attenuates myocardial infarction.