Perinatal and neonatal effects of androgens on plasma levels of testosterone, homocysteine, long bones length and diameter in male and female rats’ born

Background and aims:Homocysteine is an amino acid sulfur-containing that its amount under androgenic hormones effect changed. With regard to homocysteine effect on the growth of bone tissue, the study aimed to investigate the prenatal and neonatal effects of testosterone on serum homocysteine and growth of Femur & Humerus bones length and diameter of rats’ born were performed. Methods: The experimental study on 256 born of 40 male and female rats divided into 4 groups: control (no treatment), sham (treatment with drugs), experimental perinatal and neonatal by dosing 600 μg/kg in pregnancy and lactation periods under treatment testosterone were done. Then the different groups of both males and females’ born in the days 7,14,21 and maturation of testosterone levels, homocysteine, and length and diameter of Femur & Humerus bones were evaluated and the results obtained using SPSS-20 software and t-test, ANOVA were analyzed and the significant differences of data at P <0.05 was considered. Results: The results of data analysis showed that the significant increase in rats’ born treated with testosterone, serum levels of homocysteine and testosterone at P <0.05 is observed, but only in the male and female’ born on the 21st and during maturity, the significant reduction at P <0.05 in Femur & Humerus bones length and diameter was observed. Conclusion: The results showed that injection of testosterone during pregnancy and lactation increases testosterone levels and homocysteine and reduce the Femur & Humerus bones length and diameter.