Technical Advance Analysis of HER2 Gene Amplification Using an Automated Fluorescence in Situ Hybridization Signal Enumeration System

Rachel Stevens,* Imad Almanaseer, Miguel Gonzalez, Derin Caglar, Ryan A. Knudson, Rhett P. Ketterling, Daniel S. Schrock, Thomas A. Seemayer,* and Julia A. Bridge* From the Departments of Pathology/Microbiology,* Pediatrics, and Orthopaedic Surgery, University of Nebraska Medical Center, Omaha, Nebraska; the Department of Pathology, Advocate Lutheran General Hospital, Park Ridge, Illinois; the Department of Cytogenetics, Mayo Clinic, Rochester, Minnesota; and Abbott Laboratories Inc., Des Plaines, Illinois